Alzheimer’s Disease: Closer to the cure!

alzheimers
Image Source: Google Image

The study was conducted by the Working Group of the Neuroscience Research Australia, assisted by researchers at the University of New South Wales.

The working team to find the protein that protects the cognitive part involved from Alzheimer’s disease, that part which would erase all memories, would conduct the research.

The identified protein is the p38y chinas, which, at the time of the onset of the disease, begins to disperse and, accordingly, not to make its effect, which would be to protection against the memory.

alzheimers

Image Source: Google Image

Alzheimer’s Disease: The results of research on protein p38y chinas

During the experiment, eight healthy people were taken into careful consideration, in particular, those that still showed the cognitive skills rather shiny as others of their age. Specifically, people on ninety, or even older, but had a cognitive response and a mental capacity similar to that of the fifties.

The parties studied within the brain, the prefrontal cortex and the hippocampus, are those involved specifically in Alzheimer’s disease. The prefrontal cortex has the aim of keeping the active cognition, while the hippocampus is involved in the development and maintenance of memory.

Apparently, researchers have found that the kinase p38y, the offending protein that is responsible for the modulation of the activity of proteins, which in turn add to the organic phosphate molecules to their structure, slowly, in Alzheimer’s disease, tends to disperse, thus advancing disease.

The characteristics of Alzheimer’s disease

The Alzheimer’s disease has several features that distinguish it, the most important concern the presence of tau protein tangled on themselves within the brain and the beta-amyloid protein plaques. In the first case, the accumulation of these proteins leads to atrophy of the brain and to cell death, with inevitable consequence of the loss of memory.

The head of research, Lard Ittner, said: “studying the behavior of this protein, we found that everything we knew about Alzheimer’s disease should be reviewed. The tau protein has a protective role during the phosphorylation process, especially in the early stages of the disease. The protein protects against attacks beta-amyloid plaques thanks to the activity of the enzyme p38y”.

A part of the experiment included the reintegration of p38y protein, which promised a marked improvement in memory skills. Stimulating their activity, will be able before to delay the serious consequences of Alzheimer’s, then it is firmly seated in its progression.

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Alzheimer’s disease: A rising trend

The Alzheimer’s disease ranks among the ten leading causes of death in the United States, unlike what happens to the data on mortality related to cardiovascular diseases and cancer; it seems that the rate of deaths related to Alzheimer follow a continuous upward trend.

Alzheimer’s disease is the most common form of dementia, a group of symptoms associated with a decline in mental abilities, such as memory and reasoning.

It affects the nerves, brain cells and neurotransmitters (chemicals that carry messages to and from the brain).

Although Alzheimer’s disease is often associated with increasing age, the exact cause is unknown.

Alzheimer’s is a progressive disease, meaning that over time, growing worsens. Early symptoms include:

  • Minor memory problems
  • Difficulty in saying the exact words

These symptoms get worse when Alzheimer’s disease develops and can lead to:

  • Confusion
  • Personality changes
  • Total font change

Many of the symptoms of Alzheimer’s disease are similar to those of other diseases. The cases are different from each other; two cases are never the same, why people react in different ways to the disease. However, generally, the disease has three stages:

  1. Slight
  2. Moderate
  3. Serious

Alzheimer’s disease tends to progress slowly, which is why symptoms may not be noticed immediately. Symptoms progress plan, seven to ten years. However, their growth rate differs from person to person.

The symptoms of mild Alzheimer’s disease include:

  • Confusion
  • Low memory
  • Mood swings
  • Speech problems

These symptoms are the result of a gradual loss of brain function. The first section of the brain to deteriorate is often the part that controls memory and language functions.

When the switches to moderate stage Alzheimer’s disease, it can also cause:

  • Hallucinations in which you can hear or see things that are not
  • Disappointment: when one is convinced of things that are not real
  • Behavior obsessive or repetitive
  • Conviction of having done or experienced something that actually never happened
  • Disturbed sleep
  • Incontinence: when involuntarily urine (urinary incontinence) or defecate (fecal or bowel incontinence)

During the moderate stage, you may have trouble remembering recent things. At this stage, they can start to manifest problems of language and speech. This can lead to a feeling of frustration and depression, which involves changes in mood.

Who is suffering from severe Alzheimer’s disease may seem disoriented and show signs of increased confusion. This is also the stage at which people are much more likely to have hallucinations. They may think to hear smells, seeing or hearing things that are not or believe that someone has robbed or attacked them when, in fact, is not true.

These events may be experienced with anguish from friends and family, but also by the person himself. The hallucinations and delusions often worse at night and the person with Alzheimer’s disease may start to be violent, demanding and suspicious with all those around her.

When Alzheimer’s disease becomes severe it can cause a number of other symptoms such as:

  • Difficulty swallowing
  • Difficult to change position or move from one place to another without assistance
  • Weight loss or loss of appetite
  • Increased vulnerability to infection
  • Complete loss of short term memory and long-term

During the study severe Alzheimer’s disease, people often begin to neglect their own hygiene. It is a stage where a lot of people with the disease who need assistance throughout the day because they can do things very few independently.

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